(R)-6-(N-(2-氯-4-氟苯基)氨磺酰基)环己-1-烯羧酸乙酯;瑞沙托维
(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate;Resatorvid (Synonyms:TAK-242; CLI-095)
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3-5days
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$200.00
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Product Availability
3-5days
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$286.00
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Product Overview
Product Name (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate;Resatorvid (Synonyms:TAK-242; CLI-095)
CAS243984-11-4
FormulaC15H17ClFNO4S
MW361.82
AppearanceOff-white to yellow solid
Storage conditionDry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
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Product details

Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.

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History
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