Product Name | Laduviglusib (Synonyms: CHIR-99021; CT99021) |
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CAS | 252917-06-9 |
Formula | C22H18Cl2N8 |
MW | 465.34 |
MDL | MFCD11846251 |
Appearance | Off-white to light brown powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
化学稳定性 | DMSO中的溶液可在-20°下稳定储存3个月。 |
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Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.
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