6-((2-((4-(2,4-二氯苯基)-5-(5-甲基-1H-咪唑-2-基)嘧啶-2-基)氨基)乙基)氨基)烟腈; 拉格鲁西布
Laduviglusib (Synonyms: CHIR-99021; CT99021)
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Product Overview
Product Name Laduviglusib (Synonyms: CHIR-99021; CT99021)
CAS252917-06-9
FormulaC22H18Cl2N8
MW 465.34
MDLMFCD11846251
AppearanceOff-white to light brown powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Security information
化学稳定性DMSO中的溶液可在-20°下稳定储存3个月。
Product details

Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.

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Related
Laduviglusib dihydrochloride | CHIR-99021 dihydrochloride | CT99021 dihydrochloride
Laduviglusib trihydrochloride | CHIR-99021 Trihydrochloride
Laduviglusib monohydrochloride | CHIR-99021 Monohydrochloride | T99021 Monohydrochloride
History
Laduviglusib (Synonyms: CHIR-99021; CT99021)