Product Name | Laduviglusib trihydrochloride | CHIR-99021 Trihydrochloride |
---|---|
CAS | 1782235-14-6 |
Formula | C22H18Cl2N8·3HCl |
MW | 574.72 |
Appearance | White to light yellow powder |
Storage condition | 4°C, sealed storage, away from moisture |
Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy.
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