2-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]-1,5-萘啶 (ALK 5抑制剂II)
RepSox (Synonyms: E-616452; SJN 2511;ALK5 Inhibitor II)
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Product Overview
Product Name RepSox (Synonyms: E-616452; SJN 2511;ALK5 Inhibitor II)
CAS446859-33-2
FormulaC17H13N5
MW 287.32
MDL MFCD09037561
Appearance Light brown to yellow powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3. At 25 μM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription.
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RepSox (Synonyms: E-616452; SJN 2511;ALK5 Inhibitor II)