Product Name | Bumetanide (Synonyms: Ro 10-6338; PF 1593) |
---|---|
CAS | 28395-03-1 |
Formula | C17H20N2O5S |
MW | 364.42 |
MDL | MFCD00078949 |
Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a Na+-K+-Cl+ cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC50s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively.
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