氨磷汀
Amifostine
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Product Overview
Product Name Amifostine
CAS20537-88-6
FormulaC5H15N2O3PS
MW214.22
MDLMFCD00233058
AppearanceWhite to off-white powder
Storage conditionPowder -20°C3 years ; 4°C 2 years ;| In solvent -80°C 6 months ; -20°C 1 month
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Product details

Amifostine (WR2721) is a potent cytoprotective and radioprotective agent, selectively safeguarding normal tissues from chemotherapy and radiation-induced damage. It acts as a prodrug, activating to WR-1065 by alkaline phosphatase, which scavenges free radicals and protects cells. Amifostine also induces HIF-α1 and p53, key regulators in the cellular response to hypoxia and DNA damage. Its antiangiogenic properties, by modulating VEGF-A, suggest potential in inhibiting tumor vasculature. Recent studies highlight its renal toxicity reduction and explore PEGylation to enhance safety and efficacy, making Amifostine a versatile protector in cancer therapies.


Related
Amifostine Trihydrate | WR2721 trihydrate
History
Amifostine
Nelarabine | 506U78 | GW 506U78 | Arranon