| Product Name | Bortezomib (Synonyms: PS-341; LDP-341; NSC 681239) |
|---|---|
| CAS | 179324-69-7 |
| Formula | C19H25BN4O4 |
| MW | 384.24 |
| MDL | MFCD09056737 |
| Appearance | White to off-white solid |
| Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.
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