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Bortezomib (Synonyms: PS-341; LDP-341; NSC 681239)
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Product Name Bortezomib (Synonyms: PS-341; LDP-341; NSC 681239)
CAS179324-69-7
FormulaC19H25BN4O4
MW384.24
MDLMFCD09056737
AppearanceWhite to off-white solid
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.
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