Feedback Chinese
(Z)-3-(((4-(N-甲基-2-(4-甲基哌嗪-1-基)乙酰氨基)苯基)氨基)(苯基)亚甲基)-2-氧代吲哚啉-6-羧酸甲酯乙磺酸盐; 尼达尼布乙磺酸盐
Nintedanib Ethanesulfonate Salt (Synonyms: Intedanib; BIBF 1120)
ChemLeader
Catalog No：
CAS No.：
MDLNo：
Formula：
MW：
Download MSDS Download COA
Size
10 mg 25 mg 50 mg 100 mg
Product Availability
In-stock
Price
$66.00
Member price
Visible after login
Product Availability
In-stock
Price
$88.00
Member price
Visible after login
Product Availability
In-stock
Price
$138.00
Member price
Visible after login
Product Availability
In-stock
Price
$198.00
Member price
Visible after login
Quantity
- +
Inquiry Add To Cart
Product Overview
Product Name Nintedanib Ethanesulfonate Salt (Synonyms: Intedanib; BIBF 1120)
CAS656247-18-6
FormulaC31H33N5O4.C2H6O3S
MW649.76 | 539.64(free)
MDLMFCD26142360
AppearanceYellow powder
Storage condition4°C, sealed storage, away from moisture
Security information
Product details

Nintedanib Ethanesulfonate Salt (BIBF 1120) is an inhibitor of the receptor tyrosine kinases VEGFR, FGFR, and PDGFR (IC50s = 13-34, 37-610, 59, and 65 nM for VEGFR1-3, FGFR1-4, PDGFRα, and PDGFRβ, respectively).1 It is selective for VEGFR, FGFR, and PDGFR over a panel of 33 kinases but does inhibit FLT3, LCK, LYN, and Src (IC50s = 16-156 nM). BIBF 1120 inhibits growth factor-dependent proliferation of human umbilical vascular endothelial cells (HUVECs), human microvascular skin endothelial cells (HSMECs), human umbilical artery smooth muscle cells (HUASMCs), and bovine retinal pericytes (BRPs; EC50s = 7-290 nM). In vivo, BIBF 1120 (100 mg/kg) reduces tumor microvessel density and the number of PDGFRβ-expressing perivascular cells in a FaDu head and neck small cell carcinoma mouse xenograft model. It also inhibits tumor growth in a Caki-1 renal cancer mouse xenograft model. Formulations containing BIBF 1120 have been used in the treatment of idiopathic pulmonary fibrosis and non-small cell lung cancer (NSCLC).
buy Nintedanib Ethanesulfonate Salt | Nintedanib Ethanesulfonate Salt supplier | purchase Nintedanib Ethanesulfonate Salt | Nintedanib Ethanesulfonate Salt cost | Nintedanib Ethanesulfonate Salt manufacturer | order Nintedanib Ethanesulfonate Salt | Nintedanib Ethanesulfonate Salt distributor



Related literature
Effect of a novel oral chemotherapeutic agent containing a combination of trifluridine, tipiracil and the novel triple angiokinase inhibitor nintedanib, on human colorectal cancer xenografts
PMID: 27805254 PMCID: PMC5112602 DOI: 10.3892/or.2016.5208
Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120).
PMID: 19522465 DOI: 10.1021/jm900431g
BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.
PMID: 18559524 DOI: 10.1158/0008-5472.CAN-07-6307
Related
Nintedanib (Synonyms: BIBF 1120; Intedanib)
History
Nintedanib Ethanesulfonate Salt (Synonyms: Intedanib; BIBF 1120)
Torin 2
Pemetrexed Disodium
IRAK-1-4 Inhibitor I | IRAK-1/4 Inhibitor
Getting Started
Shopping Process
How to Inquire
How to Search
Terms of Sale
Payment Process
Request Invoice
After Sales
Delivery Introduction
Product Inspection
Return and Exchange
About Us
Company Profile
Mission and Vision
Company Brand
Company Culture
Quality System
Reference
COA Search
SDS Search
Risk Phrases
GHS Protection Code
Contact Us
+86-21-58180488
sales@Medchemleader.com
+86-21-58180499

© Copyright 2015-2021 Chemleader Biomedical Co., Ltd. All Rights Reserved.

沪ICP备15046197号-4
沪公网安备31011502007856号

Designed by Kuanersoft

Links PubChem ScienceDirect Chemleader ChemBest Herbleader ChemBestBuy
Products are for research use only. Not for human use. We do not sell to patients.