Product Name | Tivozanib (AV-951) |
---|---|
CAS | 475108-18-0 |
Formula | C22H19ClN4O5 |
MW | 454.86 |
Appearance | Light brown to brown powder |
Storage condition | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
Tivozanib is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 30 nM/6.5 nM/15 nM, and also inhibits PDGFR and c-Kit, low activity observed against FGFR-1, Flt3, c-Met, EGFR and IGF-1R. Phase 3.
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