β-拉帕醌;β-拉帕康
β-Lapachone (Synonyms: Beta-Lapachone; ARQ-501; NSC-26326;ARQ 501;NSC 26326;NSC 629749;SL 11001)
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Product Name β-Lapachone (Synonyms: Beta-Lapachone; ARQ-501; NSC-26326;ARQ 501;NSC 26326;NSC 629749;SL 11001)
CAS4707-32-8
FormulaC15H14O3
MW242.27
AppearanceBrown to red powder
Storage conditionDry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
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Beta-Lapachone (β-Lapachone, ARQ-501) is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.

β-Lapachone has been used:

as an anticancer compound in catalase-inhibitable luminol/hydrogen peroxide (HRP)-dependent chemiluminometric assay in Lewis lung carcinoma (LLC) cells and isolated mitochondria

as a naphthoquinone to study its effects on the growth and differentiation of mice granulocyte and macrophage progenitor cells

as a substrate to study the enzyme activity of human recombinant NAD(P)H dehydrogenase 1 (NQO1) protein
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History
β-Lapachone (Synonyms: Beta-Lapachone; ARQ-501; NSC-26326;ARQ 501;NSC 26326;NSC 629749;SL 11001)
Hoechst 33342 (Synonyms: bisBenzimide H 33342; HOE 33342;Pibenzimol;HO342)