多韦替尼
Dovitinib Free Base/CHIR-258/TKI-258
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Product Overview
Product Name Dovitinib Free Base/CHIR-258/TKI-258
CAS405169-16-6
FormulaC21H21FN6O
MW392.43
AppearanceLight yellow to green yellow
Storage conditionDry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
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Product details

Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Phase 4.

Related
Dovitinib (TKI258) Lactate monohydrate (Synonyms: TKI258 lactate hydrate; CHIR-258 lactate hydrate;CHIR258)
History
Dovitinib Free Base/CHIR-258/TKI-258
U0126 (Synonyms: MEK1/2抑制剂 )