Product Name | Dovitinib Free Base/CHIR-258/TKI-258 |
---|---|
CAS | 405169-16-6 |
Formula | C21H21FN6O |
MW | 392.43 |
Appearance | Light yellow to green yellow |
Storage condition | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Phase 4.
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