Product Name | Ercalcitriol; 1α, 25-Dihydroxyvitamin D2 |
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CAS | 60133-18-8 |
Formula | C28H44O3 |
MW | 428.65 |
Appearance | White to off-white powder |
Storage condition | 4°C, protect from light, stored under nitrogen |
Ercalcitriol, also known as RO-17-6218 or 1,25-dihydroxyvitamin D2, is the active circulating metabolite of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D-hydroxylase in the kidney. By binding to the vitamin D receptor (VDR), 1,25-dihydroxy Vitamin D2 activates VDR to interact with the retinoid X receptor (RXR), forming the VDR/RXR/cofactor complex, which regulates gene transcription.
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