1α,25-二羟基维生素 D2
Ercalcitriol (Synonyms: 1α,25-Dihydroxy Vitamin D2)
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Product Name Ercalcitriol (Synonyms: 1α,25-Dihydroxy Vitamin D2)
CAS60133-18-8
FormulaC28H44O3
MW428.65
AppearanceWhite to off-white powder
Storage condition4°C, protect from light, stored under nitrogen
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Ercalcitriol, also known as RO-17-6218 or 1,25-dihydroxyvitamin D2, is the active circulating metabolite of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D-hydroxylase in the kidney. By binding to the vitamin D receptor (VDR), 1,25-dihydroxy Vitamin D2 activates VDR to interact with the retinoid X receptor (RXR), forming the VDR/RXR/cofactor complex, which regulates gene transcription.
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History
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