Product Name | Nemorubicin | Methoxymorpholinyldoxorubicin | PNU 152243 | PNU-152243A | | DMM Dox | MMRDX | FCE 23762 | PNU 152243 |
---|---|
CAS | 108852-90-0 |
Formula | C32H37NO13 |
MW | 643.64 |
MDL | MFCD00871079 |
Appearance | Orange to reddish brown powder |
Storage condition | 4°C, protect from light |
Nemorubicin (Methoxymorpholinyl doxorubicin) is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity .
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