阿贝西利甲磺酸盐
Abemaciclib Mesylate | LY2835219 Mesylate) | Abemaciclib Methanesulfonate
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5 mg 10 mg
Product Availability
3-5days
Price
$136.00
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Product Availability
3-5days
Price
$256.00
Member price
Quantity
- +
Product Overview
Product Name Abemaciclib Mesylate | LY2835219 Mesylate) | Abemaciclib Methanesulfonate
CAS1231930-82-7
FormulaC28H36F2N8O3S
MW602.70
AppearanceWhite to yellow powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Product details

Abemaciclib, also known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 inhibits CDK4 and CDK6 with low nanomolar potency. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.


Related literature
Related
LY2835219 free base | Abemaciclib | LY2835219
History
Abemaciclib Mesylate | LY2835219 Mesylate) | Abemaciclib Methanesulfonate