Product Name | A-485; N-(4-Fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide |
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CAS | 1889279-16-6 |
Formula | C25H24F4N4O5 |
MW | 536.48 |
Appearance | White to off-white powder |
Storage condition | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
A-485 is a p300/CBP histone acetyltransferase (HAT) inhibitor that inhibits p300 and CBP (IC50=9.8/2.6 nM) selectively. A-485 has antitumor effects, including several hematologic malignancies and androgen receptor-positive prostate cancer.
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