Product Name | Ulixertinib (Synonyms: BVD-523; VRT752271) |
---|---|
CAS | 869886-67-9 |
Formula | C21H22Cl2N4O2 |
MW | 433.33 |
Ulixertinib (BVD-523; VRT752271) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib (BVD-523; VRT752271) inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line.
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