Ulixertinib (BVD-523, VRT752271)
Ulixertinib (Synonyms: BVD-523; VRT752271)
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Product Name Ulixertinib (Synonyms: BVD-523; VRT752271)
CAS869886-67-9
FormulaC21H22Cl2N4O2
MW433.33
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Ulixertinib (BVD-523; VRT752271) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib (BVD-523; VRT752271) inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line.

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Ulixertinib hydrochloride (Synonyms: BVD-523 hydrochloride; VRT752271 hydrochloride;Ulixertinib HCl salt) ; (S)-4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide hydrochloride.
History
Ulixertinib (Synonyms: BVD-523; VRT752271)
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