Product Name | Nedisertib (Synonyms: Peposertib; M3814; MSC2490484A) |
---|---|
CAS | 1637542-33-6 |
Formula | C24H21ClFN5O3 |
MW | 481.91 |
Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity.
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