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(1′R,6R,6aR,7R,13S,14S,16R)-5-(乙酰氧基)-3′,4′,6,6a,7,13,14,16-八氢-6′,8,14-三羟基-7′,9-二甲氧基-4,10,23-三甲基螺[6,16-(环硫基丙氧基甲桥)-7,13-亚氨基-12H-1,3-二氧杂环戊并[7,8]异喹啉并[3,2-b][3]苯并氮杂辛环-20,1′(2′H)-异喹啉]-19-酮;他比特啶 | 曲贝替定
(1′R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one;Trabectedin (Synonyms: Ecteinascidin 743; ET-743)
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Product Name (1′R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one;Trabectedin (Synonyms: Ecteinascidin 743; ET-743)
CAS114899-77-3
FormulaC39H43N3O11S
MW761.84
AppearanceWhite to light yellow powder
Storage condition-20°C, protect from light, stored under nitrogen
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Trabectedin (Ecteinascidin 743; ET-743) is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has the potential for soft tissue sarcoma and ovarian cancer research.


Related literature
A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett.
PMID: 23792433 DOI: 10.1016/j.toxlet.2013.06.213
Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and NSC 125973 in human breast cancer cell linesin vitro and in vivo.
PMID: 12460906
Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells.
PMID: 20215499 DOI: 10.1158/0008-5472.CAN-09-2335
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(1′R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one;Trabectedin (Synonyms: Ecteinascidin 743; ET-743)
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