Product Name | Trabectedin (Synonyms: Ecteinascidin 743; ET-743) |
---|---|
CAS | 114899-77-3 |
Formula | C39H43N3O11S |
MW | 761.84 |
Appearance | White to light yellow powder |
Storage condition | -20°C, protect from light, stored under nitrogen |
Trabectedin (Ecteinascidin 743; ET-743) is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has the potential for soft tissue sarcoma and ovarian cancer research.
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