沃诺拉赞盐酸盐
Vonoprazan hydrochloride | TAK-438 hydrochloride
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Product Name Vonoprazan hydrochloride | TAK-438 hydrochloride
CAS1957202-44-6
FormulaC17H16FN3O2S·HCl
MW381.85 | 345.39 (Free)
Storage conditionStore in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.
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Vonoprazan hydrochloride, a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan hydrochloride inhibits H+, K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan hydrochloride is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan hydrochloride can be used for eradication of Helicobacter pylori.



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History
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