Product Name | Obeticholic Acid (Synonyms: INT-747; 6-ECDCA;6-Ethylchenodeoxycholic acid) |
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CAS | 459789-99-2 |
Formula | C26H44O4 |
MW | 420.63 |
MDL | MFCD16621104 |
Appearance | White to off-white powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Obeticholic acid (OCA), a potent FXR agonist with an EC50 of 99 nM, targets bile acid synthesis and exhibits anticholeretic and anti-inflammatory effects, inducing autophagy. Its bioactivity is optimized through ROS-responsive nanoparticle delivery, enhancing liver targeting and reducing hepatotoxicity, offering a promising therapeutic strategy for cholestatic liver diseases.
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