4-[6-(4-(哌嗪-1-基)苯基]吡唑并[1,5-a]嘧啶-3-基)喹啉
LDN-193189(DM3189)
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Product Overview
Product Name LDN-193189(DM3189)
CAS1062368-24-4
FormulaC25H22N6
MW406.48
AppearanceLight yellow to yellow powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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LDN-193189 (DM3189) is a selective BMP signaling inhibitor, inhibits the ALK1ALK2ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.  

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