| Product Name | (E/Z)-Afatinib (Synonyms: (E/Z)-BIBW 2992; (S)-阿法替尼) |
|---|---|
| CAS | 439081-18-2 |
| Formula | C24H25ClFN5O3 |
| MW | 485.94 |
| Appearance | White to off-white powder |
| Storage condition | 4°C, protect from light |
(E/Z)-Afatinib ((E/Z)-BIBW 2992) is the mixture of (E)-Afatinib and (Z)-Afatinib. Afatinib (HY-10261) is an irreversible inhibitor of EGFR, by irreversibly binding to their ATP binding site to block activation of EGFR, HER2, HER4, and EGFRvIII. Afatinib used in co-administration with Temozolomide (HY-17364), potently targeting to EGFRvIII-cMet signaling in glioblastoma cells.
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