凡德他尼
Vandetanib (ZD6474)
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$300.00
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$900.00
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$1500.00
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Product Overview
Product Name Vandetanib (ZD6474)
CAS443913-73-3
FormulaC22H24BrFN4O2
MW475.35
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Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).

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Vandetanib (ZD6474)