| Product Name | LY2109761 |
|---|---|
| CAS | 700874-71-1 |
| Formula | C26H27N5O2 |
| MW | 441.52 |
| Appearance | White to yellow powder |
| Storage condition | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis.
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