瓦他拉尼二盐酸盐
Vatalanib Dihydrochloride | Vatalanib 2HCl
ChemLeader
Catalog No:
CAS No.:
MDLNo:
Formula:
MW:
Size
20 mg 50 mg 100 mg
Product Availability
In-stock
Price
$56.00
Member price
Product Availability
In-stock
Price
$63.00
Member price
Product Availability
In-stock
Price
$86.00
Member price
Quantity
- +
Product Overview
Product Name Vatalanib Dihydrochloride | Vatalanib 2HCl
CAS212141-51-0
FormulaC20H17Cl3N4
MW419.73
AppearanceOff-white to pink powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Security information
Product details

Vatalanib (PTK787 or ZK-222584, cpg-79787 2HCl) 2HCl is a novel, potent and orally bioavailable inhibitor of VEGFR2/KDR with potential anticancer activity. In a cell-free experiment, it inhibits VEGFR2/KDR with an IC50 of 37 nM, is less effective against VEGFR1/Flt-1, and is 18-fold more potent against VEGFR3/Flt-4. With strong anti-proliferative activity in vitro and strong antitumor efficaciousness in vivo, it is an anilinophthalazine analog. The protein kinase domains of VEGFR 1 and 2 are bound by vatalanib, which then inhibits them. The PDGF receptor, c-Kit, and c-Fms are among the related receptor tyrosine kinases that this agent binds to and inhibits.

Related literature
Related
Sorry, no related items
History
Vatalanib Dihydrochloride | Vatalanib 2HCl
Bevacizumab (anti-VEGF) | RhuMab VEGF