(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(烯丙基氨基)-13-羟基-8,14-二甲氧基-4,10,12,16-四甲基-3,20,22-三氧代-2-氮杂双环[16.3.1]二十二烷-1(21),4,6,10,18-戊烯-9-基 氨基甲酸酯;坦螺旋霉素
Tanespimycin (Synonyms: 17-AAG; NSC 330507; CP 127374;KOS-953; KOS 953)
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Product Overview
Product Name Tanespimycin (Synonyms: 17-AAG; NSC 330507; CP 127374;KOS-953; KOS 953)
CAS75747-14-7
FormulaC31H43N3O8
MW585.69
MDLMFCD04973892
AppearancePurple to purplish red powder
Storage condition4°C, protect from ligh
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Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosisnecrosisautophagy and mitophagy.

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Tanespimycin (Synonyms: 17-AAG; NSC 330507; CP 127374;KOS-953; KOS 953)