Product Name | Tanespimycin (Synonyms: 17-AAG; NSC 330507; CP 127374;KOS-953; KOS 953) |
---|---|
CAS | 75747-14-7 |
Formula | C31H43N3O8 |
MW | 585.69 |
MDL | MFCD04973892 |
Appearance | Purple to purplish red powder |
Storage condition | 4°C, protect from ligh |
Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy.
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