盐酸吉西他滨
Gemcitabine Hydrochloride | Gemcitabine HCl | LY 188011 hydrochloride | NSC 613327 HCl
ChemLeader
Catalog No:
CAS No.:
MDLNo:
Formula:
MW:
Size
250 mg 500 mg 1 g 5 g
Product Availability
In-stock
Price
$260.00
Member price
Product Availability
In-stock
Price
$400.00
Member price
Product Availability
In-stock
Price
$750.00
Member price
Product Availability
In-stock
Price
$3100.00
Member price
Quantity
- +
Product Overview
Product Name Gemcitabine Hydrochloride | Gemcitabine HCl | LY 188011 hydrochloride | NSC 613327 HCl
CAS122111-03-9
FormulaC₉H₁₂ClF₂N₃O₄
MW299.66
AppearanceWhite to off-white powder
Storage condition 4°C, sealed storage, away from moisture and light
Security information
Product details

Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031   and gemcitabine elaidate   and a prodrug form of gemcitabine di- and triphosphates. Gemcitabine is phosphorylated by intracellular kinases to the intermediate metabolite gemcitabine monophosphate   and the active di- and triphosphate forms.It is cytotoxic to HepG2 hepatocellular carcinoma and A549 non-small cell lung cancer (NSCLC) cells (IC50s = 5.2 and 16 nM, respectively) and inhibits tumor growth in various breast, colon, lung, and pancreatic cancer mouse xenograft models. Gemcitabine (12 mg/kg) sensitizes tumors to antibodies targeting programmed cell death protein 1 (PD-1), decreases the number of tumor-infiltrating regulatory T cells (Tregs), and increases survival in an MC-38 syngeneic mouse model of colon carcinoma.  Formulations containing gemcitabine have been used in the treatment of cancer.

Related literature
Related
Sorry, no related items
History
Tamoxifen
Gemcitabine Hydrochloride | Gemcitabine HCl | LY 188011 hydrochloride | NSC 613327 HCl
BMS-1166 hydrochloride
Pristimerin (Synonyms: Celastrol methyl ester)
MC-GGFG-OSu (MC-Gly-Gly-Phe-Gly-OSu); 2,5-Dioxopyrrolidin-1-yl (S)-5-Benzyl-18-(2,5-dioxo-2,5-dihydro-1-pyrrolyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazaoctadecan-1-oate
(-)-(S)-Equol | AUS 131 | SE 5OH
Luminol sodium salt; Luminol monosodium salt
Inavolisib | GDC-0077 | RG6114 | RO-7113755
Fmoc-Ser(PO(OBzl)OH)-OH; Fmoc-Ser(HPO3Bzl)-OH;N-α-Fmoc-O-benzyl-L-phosphoserine
Anti-Human EGFRxMET Bispecific Antibody(Amivantamab; JNJ-61186372)