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氯氮平N-氧化盐酸

Clozapine N-oxide dihydrochloride

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Catalog No：CL2075A

CAS No.：2250025-93-3

MDLNo：

Formula：C18H19ClN4O · 2HCl

MW：415.74 | 342.83(free)

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Product Overview

Product Name	Clozapine N-oxide dihydrochloride
CAS	2250025-93-3
Formula	C18H19ClN4O · 2HCl
MW	415.74 \| 342.83(free)
Appearance	Light yellow to yellow powder
Storage condition	4°C, stored under nitrogen

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Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist.

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