司他生坦钠 | 西他塞坦钠
Sitaxsentan sodium (Synonyms: IPI 1040 sodium; TBC11251 sodium)
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Product Overview
Product Name Sitaxsentan sodium (Synonyms: IPI 1040 sodium; TBC11251 sodium)
CAS210421-74-2
FormulaC18H14ClN2NaO6S2
MW476.89
AppearanceLight yellow to yellow powder
Storage condition4°C, sealed storage, away from moisture
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Product details

Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally activeendothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan sodium exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan sodium inhibits ET-1-induced phosphoinositide turnover. Sitaxsentan sodium can significantly alleviate pulmonary arterial hypertension (PAH) symptoms. Sitaxsentan sodium can be used for the study of PAH.

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Sitaxsentan (Synonyms: IPI 1040; TBC-11251)
History
Sitaxsentan sodium (Synonyms: IPI 1040 sodium; TBC11251 sodium)
2-Deoxy-2-fluoro-L-fucose