| Product Name | Sitaxsentan sodium (Synonyms: IPI 1040 sodium; TBC11251 sodium) |
|---|---|
| CAS | 210421-74-2 |
| Formula | C18H14ClN2NaO6S2 |
| MW | 476.89 |
| Appearance | Light yellow to yellow powder |
| Storage condition | 4°C, sealed storage, away from moisture |
Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally activeendothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan sodium exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan sodium inhibits ET-1-induced phosphoinositide turnover. Sitaxsentan sodium can significantly alleviate pulmonary arterial hypertension (PAH) symptoms. Sitaxsentan sodium can be used for the study of PAH.
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