陶扎色替
Tozasertib(VX-680;MK-0457)
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Product Overview
Product Name Tozasertib(VX-680;MK-0457)
CAS639089-54-6
FormulaC23H28N8OS
MW464.59
AppearanceWhite to off-white powder
Storage condition Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Tozasertib (VX-680) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy.  

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History
Tozasertib(VX-680;MK-0457)
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Fmoc-L-Arg(Me, Me)-OH (symmetrical)