陶扎色替
Tozasertib(VX-680;MK-0457)
ChemLeader
Catalog No:
CAS No.:
MDLNo:
Formula:
MW:
Size
25 mg 50 mg 100 mg 500 mg
Product Availability
In-stock
Price
$300.00
Member price
Product Availability
In-stock
Price
$450.00
Member price
Product Availability
In-stock
Price
$550.00
Member price
Product Availability
In-stock
Price
$2200.00
Member price
Quantity
- +
Product Overview
Product Name Tozasertib(VX-680;MK-0457)
CAS639089-54-6
FormulaC23H28N8OS
MW464.59
AppearanceWhite to off-white powder
Storage condition Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Security information
Product details

Tozasertib (VX-680) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy.  

Related literature
Related
Sorry, no related items
History
Neratinib (Synonyms: HKI-272)
A-485; N-(4-Fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide
Cabergoline
Tozasertib(VX-680;MK-0457)
StreptoMycin sulfate | NSC 14083
Telaprevir | VX-950 | LY-570310 | MP-424
Orantinib | SU 6668 | TSU-68
Tariquidar dimesylate | XR9576 dimesylate
Vicriviroc maleate (Synonyms: SCH-417690 maleate ; SCH-D maleate; 维立韦罗马来酸盐)
Poseltinib | HM71224 | LY3337641