米托蒽醌二盐酸盐/盐酸米托蒽醌
Mitoxantrone Dihydrochloride; Mitoxantrone 2HCl
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Product Overview
Product Name Mitoxantrone Dihydrochloride; Mitoxantrone 2HCl
CAS70476-82-3
FormulaC22H29ClN4O6.2HCl
MW517.4
AppearanceDark blue powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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 Mitoxantrone is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5.3 μM), thus inhibiting cell proliferation. It also inhibits HIV-1 integrase (IC50 = 3.8 μM). Mitoxantrone is exported from cells in an ATP- and glutathione-dependent manner by multidrug resistance protein-1.4 Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis.

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