N-(6-甲基-2-苯并噻唑基)-2-[(3,4,6,7-四氢-4-氧代-3-苯基噻吩并[3,2D]嘧啶-2-基)硫基]乙酰胺
N-(6-Methyl-2-benzothiazolyl)-2-[(3​,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2- d ]pyrim​idin-2-yl)thio]-acetamide; IWP-2
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Product Name N-(6-Methyl-2-benzothiazolyl)-2-[(3​,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2- d ]pyrim​idin-2-yl)thio]-acetamide; IWP-2
CAS686770-61-6
FormulaC22H18N4O2S3
MW466.60
AppearanceWhite powder
Storage condition Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. IWP-2 specifically inhibits CK1δ.

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