Product Name | Nigericin Sodium Salt |
---|---|
CAS | 28643-80-3 |
Formula | C40H67NaO11 |
MW | 746.94 |
Appearance | White to off-white powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Nigericin is a cationic ionophore that inhibits Golgi function and suppresses growth of gram positive bacteria. It also prevents viral activation and triggers activation of the NALP3 inflammasome. Nigericin acts as an H+, K+, Pb2+ ionophore. Most commonly it is an antiporter of H+ and K+. In the past nigericin was used as an antibiotic active against gram positive bacteria. It inhibits the Golgi functions in Eukaryotic cells. Its ability to induce K+ efflux also makes it a potent activator of the NLRP3 inflammasome.
© Copyright 2015-2021 Chemleader Biomedical Co., Ltd. All Rights Reserved.
沪ICP备15046197号-4
沪公网安备31011502007856号
Designed by Kuanersoft