奥拉帕尼
Olaparib (Synonyms: AZD2281; KU0059436; Ku-0059436)
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Product Name Olaparib (Synonyms: AZD2281; KU0059436; Ku-0059436)
CAS763113-22-0
FormulaC₂₄H₂₃FN₄O₃
MW434.46
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.
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History
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