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(3R,6R)-6-((1R,3aS,7aR,E)-4-((Z)-2-((S)-5-羟基-2-亚甲基亚环己基)亚乙基)-7a-甲基八氢-1H-茚-1-基)-2-甲基庚烷-2,3-二醇; 司骨化醇

Secalciferol (Synonyms: (24R)-24,25-Dihydroxyvitamin D3)

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Catalog No：CL2279

CAS No.：55721-11-4

MDLNo：MFCD00941417

Formula：C₂₇H₄₄O₃

MW：416.64

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Product Name	Secalciferol (Synonyms: (24R)-24,25-Dihydroxyvitamin D3)
CAS	55721-11-4
Formula	C₂₇H₄₄O₃
MW	416.64
MDL	MFCD00941417
Appearance	White to off-white powder
Storage condition	-20°C, protect from light, stored under nitrogen

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Secalciferol, also known as (24R)-24,25-Dihydroxyvitamin D3, is the primary active form of Vitamin D. This compound potently activates the vitamin D receptor (VDR) with an EC50 value of 150 nM. It plays a crucial role in various biological processes, including the regulation of calcium homeostasis, cellular differentiation, and proliferation. Additionally, Secalciferol has significant implications for the immune system, making it a promising area of research for conditions such as rickets, osteomalacia, hypercalcemia, and autoimmune disorders.

Related literature

Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24[J].

PMID: 27327272 DOI: 10.1021/acs.chemrestox.6b00170

In vitro and in vivo glucuronidation of 24,25-dihydroxyvitamin D3[J].

PMID: 10498030 DOI: 10.1016/s0039-128x(99)00057-4

Influences of long-term administration of 24R, 25-dihydroxyvitamin D3, a vitamin D3 derivative, in rats[J].

J Toxicol Sci. 1999 May;24(2):133-9.

24, 25-Dihydroxy VD3

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24, 25-Dihydroxy VD2; 24,25-Dihydroxy vitamin D2;24,25-Dihydroxyvitamin D2; (4E,6R)-2,3-Dimethyl-6-[(1R,3aS,4E,7aR)-octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-7a-methyl-1H-inden-1-yl]-4-heptene-2,3-diol

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Secalciferol (Synonyms: (24R)-24,25-Dihydroxyvitamin D3)

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