(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-二羟基-3-((R)-1-((1S,3R,4R)-4-(2-羟基乙氧基)-3-甲氧基环己基)丙-2-基)-10,21-二甲氧基-6,8,12,14,20,26-六甲基-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-十六氢-3H-23,27-环氧吡啶并[21-c][1]氧杂]4]氮杂环;依维莫司
Everolimus | RAD-001
ChemLeader
Catalog No:
CAS No.:
MDLNo:
Formula:
MW:
Size
10 mg 25 mg
Product Availability
In-stock
Price
$76.00
Member price
Product Availability
In-stock
Price
$126.00
Member price
Quantity
- +
Product Overview
Product Name Everolimus | RAD-001
CAS159351-69-6
FormulaC53H83NO14
MW958.22
MDLMFCD00929329
AppearanceWhite to off-white powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Security information
Product details

 Everolimus, also known as RAD001, is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production.


Related
Sorry, no related items
History
Everolimus | RAD-001