奥巴克拉甲磺酸盐
Obatoclax mesylate (GX15-070)
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Product Overview
Product Name Obatoclax mesylate (GX15-070)
CAS803712-79-0
FormulaC20H19N3O.CH4O3S
MW413.49
Appearance Purple to black powder
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Obatoclax, also known as GX 015-070, a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and antineoplastic activities. Obatoclax binds to members of the Bcl-2 protein family, preventing the binding of these anti-apoptotic proteins to the pro-apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl-2-overexpressing cells. The Bcl-2 family of proteins (bcl-2, bcl-xl, bcl-w, and Mcl-1) are overexpressed in a wide variety of cancers, including those of the lymphatic system, breast, lung, prostate, and colon.

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History
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