5-((5-氯-1H-吡咯并[2,3-b]吡啶-3-基)甲基)-N-((6-(三氟甲基)吡啶-3-基)甲基)吡啶-2-胺
Pexidartinib (Synonyms: PLX-3397)
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Product Name Pexidartinib (Synonyms: PLX-3397)
CAS1029044-16-3
FormulaC20H15ClF3N5
MW417.81
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Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity.

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History
Pexidartinib (Synonyms: PLX-3397)
Ziconotide Acetate
HG-9-91-01 | SIK inhibitor 1
Pimecrolimus | SDZ-ASM 981 | ASM 981 | SDZ-ASM 981
Nepicastat Hydrochloride (Synonyms: Nepicastat HCl; SYN-117 hydrochloride; RS-25560-197 hydrochloride)
SIS3 HCl
A-1155463
Benidipine Hydrochloride | Benidipine HCl | KW3049
MMAF (Synonyms: Monomethylauristatin F)
Ursodeoxycholic acid (Synonyms:Ursodeoxycholate; Ursodiol; UDCA;3,7-Dihydroxycholan-24-oic acid; 3alpha,7beta-Dihydroxy-6beta-cholan-24-oic acid)