N-[(苄氧基)羰基]-L-亮氨酰-N-[(1S)-1-甲酰基-3-甲基丁基]-L-亮氨酰胺
MG-132 (Synonyms: Z-Leu-Leu-Leu-al; MG132)
ChemLeader
Catalog No:
CAS No.:
MDLNo:
Formula:
MW:
Size
5 mg 10 mg 25 mg 50 mg
Product Availability
In-stock
Price
$46.00
Member price
Product Availability
In-stock
Price
$68.00
Member price
Product Availability
In-stock
Price
$108.00
Member price
Product Availability
In-stock
Price
$172.00
Member price
Quantity
- +
Product Overview
Product Name MG-132 (Synonyms: Z-Leu-Leu-Leu-al; MG132)
CAS133407-82-6
FormulaC26H41N3O5
MW475.62
MDLMFCD00674886
AppearanceWhite to yellow powder
Storage conditionStore short-term at 0-4°C or long-term at -20°C in a dry, dark place.
Security information
Product details

MG-132, a potent proteasome and calpain inhibitor, boasts IC50s of 100 nM and 1.2 μM, respectively. This peptide aldehyde effectively halts the 26S proteasome complex's proteolytic activity. Beyond its inhibitory role, MG-132 activates autophagy and triggers apoptosis. Studies reveal that MG-132 can activate autophagy in vascular smooth muscle cells, inhibiting senescence through the PI3K/AKT/mTOR pathway. It also induces apoptosis in a cell cycle-dependent manner, highlighting its multifaceted bioactivity in cellular regulation.

Related
Sorry, no related items
History
MG-132 (Synonyms: Z-Leu-Leu-Leu-al; MG132)
Dydrogesterone | NSC 92336
Furanodiene
Rivulobirin E
Eseroline
Capecitabine | RO 09-1978 | Xeloda
Telaprevir | VX-950 | LY-570310 | MP-424
Exbivirumab
(-)-Isocorypalmine | Tetrahydrocolumbamine | (S)-Tetrahydrocolumbamine | L-Isocorypalmine | L-Tetrahydrocolumbamine
Metformin Hydrochloride (Metformin HCl; 1,1-Dimethylbiguanide HCl)