N-[(苄氧基)羰基]-L-亮氨酰-N-[(1S)-1-甲酰基-3-甲基丁基]-L-亮氨酰胺
MG-132 (Synonyms: Z-Leu-Leu-Leu-al; MG132)
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Product Overview
Product Name MG-132 (Synonyms: Z-Leu-Leu-Leu-al; MG132)
CAS133407-82-6
FormulaC26H41N3O5
MW475.62
MDLMFCD00674886
AppearanceWhite to yellow powder
Storage conditionStore short-term at 0-4°C or long-term at -20°C in a dry, dark place.
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MG-132, a potent proteasome and calpain inhibitor, boasts IC50s of 100 nM and 1.2 μM, respectively. This peptide aldehyde effectively halts the 26S proteasome complex's proteolytic activity. Beyond its inhibitory role, MG-132 activates autophagy and triggers apoptosis. Studies reveal that MG-132 can activate autophagy in vascular smooth muscle cells, inhibiting senescence through the PI3K/AKT/mTOR pathway. It also induces apoptosis in a cell cycle-dependent manner, highlighting its multifaceted bioactivity in cellular regulation.     Tags: buy MG-132 | purchase MG-132 | MG-132 cost | order MG-132 | MG-132 chemical structure | MG-132 in vivo | MG-132 in vitro | MG-132 formula | MG-132 molecular weight

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MG-132 (Synonyms: Z-Leu-Leu-Leu-al; MG132)
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