| Product Name | Midostaurin (Synonyms: PKC412; CGP 41251) |
|---|---|
| CAS | 120685-11-2 |
| Formula | C35H30N4O4 |
| MW | 570.64 |
| Appearance | White to yellow powder |
| Storage condition | -20°C, sealed storage, away from moisture |
PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.
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