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H-89二盐酸盐

H-89 Dihydrochloride (Synonyms: H 89 2HCl)

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Catalog No：CL2397A

CAS No.：130964-39-5

MDLNo：

Formula：C20H20BrN3O2S· 2HCl

MW：519.28 | 446.36(free)

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Price

$106.00

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Product Availability

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Price

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Product Name	H-89 Dihydrochloride (Synonyms: H 89 2HCl)
CAS	130964-39-5
Formula	C20H20BrN3O2S· 2HCl
MW	519.28 \| 446.36(free)
Appearance	White to light yellow powder
Storage condition	4°C, sealed storage, away from moisture

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Product details

H-89 Dihydrochloride (H 89 2HCl) is a potent and selective inhibitor of protein kinase A (PKA) with an IC₅₀ of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase.
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Related literature

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

PMID: 2156866

Specificity and mechanism of action of some commonly used protein kinase inhibitors.

PMID: 10998351 PMCID: PMC1221339 DOI: 10.1042/0264-6021:3510095

Effects of BL-191 and H-89 on epileptogenic activity of bucladesine in pentylenetetrazol-treated mice.

PMID: 21946102 DOI: 10.1016/j.ejphar.2011.09.026

Effects of the PKA inhibitor H-89 on excitation-contraction coupling in skinned and intact skeletal muscle fibres.

PMID: 11763200 DOI: 10.1023/a:1012289526618

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