Product Name | Dovitinib (TKI258) Lactate monohydrate (Synonyms: TKI258 lactate hydrate; CHIR-258 lactate hydrate;CHIR258) |
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CAS | 915769-50-5 |
Formula | C24H29FN6O5 |
MW | 500.52 |
MDL | MFCD16038433 |
Appearance | Light yellow to yellow powder |
Storage condition | 4°C, sealed storage, away from moisture |
Dovitinib lactate hydrate (TKI258 lactate hydrate) is a potent multi-targeted tyrosine kinase inhibitor with IC50 values of 1 nM for FLT3, 2 nM for c-Kit, 8-9 nM for FGFR1/3, 10-13 nM for VEGFR1/2/3, and 27-210 nM for PDGFRα/β, respectively.
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