CB-839
Telaglenastat (Synonyms: CB-839)
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5 mg 10 mg
Product Availability
3-5days
Price
$128.00
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Product Availability
3-5days
Price
$236.00
Member price
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Product Overview
Product Name Telaglenastat (Synonyms: CB-839)
CAS1439399-58-2
FormulaC26H24F3N7O3S
MW571.57
AppearanceOff-white to yellow powder
Storage conditionStore in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.
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Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity.
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History
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