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Erlotinib Hydrochloride (Synonyms: Erlotinib HCl; CP-358774 hydrochloride; NSC 718781 hydrochloride; OSI-774 hydrochloride; OSI-774 HCl)
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Product Name Erlotinib Hydrochloride (Synonyms: Erlotinib HCl; CP-358774 hydrochloride; NSC 718781 hydrochloride; OSI-774 hydrochloride; OSI-774 HCl)
CAS183319-69-9
FormulaC22H23N3O4·HCl
MW429.90
AppearanceWhite to off-white powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Erlotinib HCl (formerly OSI-744, OSI744; trade name: Tarceva), the hydrochloride salt of erlotinib, is an EGFR (epidermal growth factor receptor) inhibitor with antitumor activity. In cell-free experiments, it inhibits EGFR with an IC50 of 2 nM, and when compared to human c-Src or v-Abl, it is >1000 times more sensitive to inhibit EGFR. The FDA and other nations have authorized erlotinib, a quinazoline derivative, for the treatment of pancreatic cancer, non-small cell lung cancer (NSCLC), and various other cancer types.
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History
Erlotinib Hydrochloride (Synonyms: Erlotinib HCl; CP-358774 hydrochloride; NSC 718781 hydrochloride; OSI-774 hydrochloride; OSI-774 HCl)
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