Product Name | Sofosbuvir (Synonyms: PSI-7977; GS-7977) |
---|---|
CAS | 1190307-88-0 |
Formula | C22H29FN3O9P |
MW | 529.45 |
MDL | MFCD26523124 |
Appearance | White to off-white powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Sofosbuvir, a nucleotide analog prodrug, is known for its potent inhibition of HCV NS5B polymerase. It has been optimized for bioactivity by modifying its structure to enhance cellular uptake and resistance to exonuclease proofreading.The compound is metabolized to an active triphosphate form that terminates viral RNA replication.
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