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Orlistat (Synonyms: Tetrahydrolipstatin; Ro-18-0647)
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5 g 10 g 25 g
Product Availability
3-5days
Price
$100.00
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Product Availability
3-5days
Price
$120.00
Member price
Product Availability
3-5days
Price
$200.00
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Product Overview
Product Name Orlistat (Synonyms: Tetrahydrolipstatin; Ro-18-0647)
CAS96829-58-2
FormulaC29H53NO5
MW495.73
AppearanceWhite to off-white powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Orlistat (also known as tetrahydrolipstatin, or Ro 18-0647, Lipase Inhibitor, THL ) is a potent and general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. Orlistat is a drug designed to treat obesity. Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini. Mechanistic studies suggest that Orlistat inhibits the thioesterase domain of fatty acid synthase (FAS) and as a result halts cell proliferation and causes cell apoptosis. More detailed experiments show that gradually Orlistat affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary.
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