Product Name | A-484954; 7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide |
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CAS | 142557-61-7 |
Formula | C13H15N5O3 |
MW | 289.29 |
MDL | MFCD22683836 |
A-484954 is a highly selective eukaryotic elongationfactor-2 kinase(eEF2K) inhibitor, with an IC50 of 280 nM.
A cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.
Keywords: buy A-484954 | A-484954 supplier | purchase A-484954 | A-484954 cost | A-484954 manufacturer | order A-484954 | A-484954 distributor | Eukaryotic elongation factor-2 kinase inhibitor | eEF2K Inhibitor
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