依伏磷酰胺 | 艾伏磷酰胺
Evofosfamide (Synonyms: TH-302)
ChemLeader
Catalog No:
CAS No.:
MDLNo:
Formula:
MW:
Size
Quantity
- +
Product Overview
Product Name Evofosfamide (Synonyms: TH-302)
CAS918633-87-1
FormulaC9H16Br2N5O4P
MW449.04
AppearanceWhite to yellow powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Security information
Product details

Evofosfamide (TH-302) is potent and selective that has an IC50 of 19 nM. It exhibits 270-fold increased cytotoxicity under hypoxia compared to their potency under aerobic conditions and is stable to cytochrome P450 metabolism. Under hypoxia, TH-302 is selectively potent and liver microsomes tolerate it well. With a high hypoxic selectivity [Hypoxia cytotoxicity ratio (HCR) = 270], replacing the chlorine with bromine in the phosphorus mustard in 3b results in a 10-fold increase in potency. Under N2, TH-302 exhibits strong cytotoxicity against human lung cancer H460 cells and human colon cancer HT29 cells. With an IC90 of 0.1 μM and 0.2 μM, respectively, TH-302 inhibits HT29 cells and H460 cells.
Tags: buy Evofosfamide (TH-302) | Evofosfamide (TH-302) supplier | purchase Evofosfamide (TH-302) | Evofosfamide (TH-302) cost | Evofosfamide (TH-302) manufacturer | order Evofosfamide (TH-302) | Evofosfamide (TH-302) distributor

Related literature
Related
Sorry, no related items
History
Cediranib | ADZ-2171 | NSC-732208
3-Deazaneplanocin A Hydrochloride (Synonyms: DZNep hydrochloride; NSC 617989 hydrochloride; 3-Deazaneplanocin hydrochloride;3-Deazaneplanocin A (DZNeP) HCl;NSC 617989 HCl)
Docetaxel Trihydrate (Synonyms: RP-56976 Trihydrate; RP56976 (NSC 628503) Trihydrate)
Parsatuzumab (Anti-EGFL7)
Ramatroban
Evofosfamide (Synonyms: TH-302)
Recombinant Human Interleukin 4 (rHulL-4)
Prucalopride(Synonyms: R093877;Motegrity; Resolor; Resotran; 普卢卡必利; 普卡必利)
Linifanib(ABT-869; AL-39324; RG3635)
PD184352(Synonyms: CI-1040)