依伏磷酰胺 | 艾伏磷酰胺
Evofosfamide (Synonyms: TH-302)
ChemLeader
Catalog No:
CAS No.:
MDLNo:
Formula:
MW:
Size
Quantity
- +
Product Overview
Product Name Evofosfamide (Synonyms: TH-302)
CAS918633-87-1
FormulaC9H16Br2N5O4P
MW449.04
AppearanceWhite to yellow powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Security information
Product details

Evofosfamide (TH-302) is potent and selective that has an IC50 of 19 nM. It exhibits 270-fold increased cytotoxicity under hypoxia compared to their potency under aerobic conditions and is stable to cytochrome P450 metabolism. Under hypoxia, TH-302 is selectively potent and liver microsomes tolerate it well. With a high hypoxic selectivity [Hypoxia cytotoxicity ratio (HCR) = 270], replacing the chlorine with bromine in the phosphorus mustard in 3b results in a 10-fold increase in potency. Under N2, TH-302 exhibits strong cytotoxicity against human lung cancer H460 cells and human colon cancer HT29 cells. With an IC90 of 0.1 μM and 0.2 μM, respectively, TH-302 inhibits HT29 cells and H460 cells.
Tags: buy Evofosfamide (TH-302) | Evofosfamide (TH-302) supplier | purchase Evofosfamide (TH-302) | Evofosfamide (TH-302) cost | Evofosfamide (TH-302) manufacturer | order Evofosfamide (TH-302) | Evofosfamide (TH-302) distributor

Related literature
Related
Sorry, no related items
History
Evofosfamide (Synonyms: TH-302)
Avatrombopag Maleate(AKR-501 maleate; E5501 maleate; YM477 maleate)
Recombinant Human Interleukin 4 (rHulL-4)
Pantoprazole Sodium | SKF96022 sodium | BY-1023 sodium
Z-FG-NHO-BzOME
GW 501516 (Synonyms: GW 1516; GSK-516; GW-501516; Cardarine)
Petunidin Chloride
Z-VAD(OMe)-FMK (Synonyms: Z-Val-Ala-Asp(OMe)-FMK;N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide)
Cediranib | ADZ-2171 | NSC-732208
Docetaxel Trihydrate (Synonyms: RP-56976 Trihydrate; RP56976 (NSC 628503) Trihydrate)