Product Name | Tesirine | SG3249 |
---|---|
CAS | 1595275-62-9 |
Formula | C75H101N9O23 |
MW | 1496.65 |
Appearance | White to light yellow powder |
Storage condition | Avoid light, nitrogen, -20 ℃ |
Tesirine (SG-3249; SG3249), cathepsin B-cleavable valine-alanine pyrrolobenzodiazepine (PBD) dimer used as an antibody-drug conjugate (ADC) payload; Tesirine was designed to combine the potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. Rovalpituzumab tesirine is a first-in-class ADC directed against delta-like protein 3 (DLL3), a novel target identified in tumour-initiating cells and expressed in small-cell lung cancer.
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