Product Name | Exatecan Mesylate (Synonyms: DX8951f) |
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CAS | 169869-90-3 |
Formula | C25H26FN3O7S |
MW | 531.55 |
MDL | MFCD04113012 |
Appearance | Light yellow to green yellow powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Exatecan, also known as DX 8951, is semisynthetic, water-soluble camptothecin derivative with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues.
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